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KMID : 0931320080080010009
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대한상부위장관.헬리코박터학회지
2008 Volume.8 No. 1 p.9 ~ p.14
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Meta-analysis of the H. pylori Eradication Rates according to the Duration of the First-line Therapy
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Jung Hae-Sun
Shim Ki-Nam
Park Hye-Sook
Kang Min-Jung
Jung Ji-Min
Ha Chang-Yoon
Na Yoon-Ju
Baik Su-Jung
Kim Seong-Eun
Jung Sung-Ae
Yoo Kwon
Moon Il-Hwan
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Abstract
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Background/Aims: PPI-based triple therapy using amoxicillin, clarithromycin is the standard first-line regimen for eradication of Helicobacter pylori in Korea. Since the optimal duration of the therapy is debatable, we conducted this study to compare the eradication rates based on different treatment durations of triple therapy.
Methods: We analyzed two abstracts and six articles published from 1996 to 2007 in Korea, to compare the eradication rates, according to the treatment duration, i.e., 7, 10, and 14 days using Mantel- Haenszel methods.
Results: The odds ratio comparing the eradication rates based on different treatment durations was 1.91 in 7 vs. 14 days, 1.49 in 7 vs. 10 days and 1.86 in 10 vs. 14 days. The eradication rate of only 14 days treatment showed more than 90% by per protocol analysis.
Conclusions: The eradication rate of 14 days treatment was higher than that of 7 and 10 days. A longer duration of therapy resulted in a higher eradication rate. However, considering the limit of metaanalysis, we should deliberate prolongation of the treatment duration of the first line Helicobacter pylori eradication therapy prudently. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2008;8:9-14)
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KEYWORD
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Helicobacter pylori, Eradication, Triple therapy, Metaanalysis
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